Kybernin P-500 powder

Marketed by Dexa Medica

Ingredients in every vial

Antithrombin III human 500 IU

Each package contains

1 vial of 500 iu

Other details

Dosage form:Powder and solvent for solution for injection
Flavour: None

W.H.O. classification

ATC Level 1: B - Blood and blood forming organs
ATC Level 2: B01 - Antithrombotic Agents
ATC Level 3: B01A - Antithrombotic Agents



CAUTIONThis item may not be safe for use during pregnancy. Use with caution and after consultation with your doctor.


CAUTIONThis item may not be safe for use during lactation. Use with caution.


CONSULT YOUR DOCTORSafety of this item for use with alcohol has not been established. Please consult your doctor.


SAFE IF PRESCRIBEDThis item is safe for use while operating heavy machinery.

Available in


Dosage information

40-60 IU antithrombin per kg of body weight per day depending on the coagulation status. If required by the clinical condition higher dosages may be necessary in individual cases. The antithrombin activity must then be monitored more frequently and should not exceed 120%.

In congenital deficiency, dosage should be individualised for each patient taking into account the family history with regard to thromboembolic events, the actual clinical risk factors and the laboratory assessment.
The dosage and duration of the substitution therapy in acquired deficiency depend on the plasma antithrombin level, the presence of signs for increased turnover, the underlying disorder, and severity of the clinical condition. The amount to be administered and the frequency of administration should always be based on the clinical efficacy and laboratory assessment in the individual case.
The number of units of antithrombin administered is expressed in International Units (IU), which are related to the current WHO standard for antithrombin. Antithrombin activity in plasma is expressed either as percentage (relative to normal human plasma) or in International Units (relative to the International Standard for antithrombin in plasma).
One international unit (IU) of antithrombin activity is equivalent to that quantity of antithrombin in one ml normal human plasma. The calculation of the required dosage of antithrombin is based on the empirical finding that 1 International unit (IU) antithrombin per kg body weight raises the plasma antithrombin activity by approximately 1.5%.

The initial dose is determined using the following formula:
Required units = body weight [kg] x (100-actual antithrombin activity [%]) x 2/3.

The initial target antithrombin activity depends on the clinical situation. When the indication for antithrombin substitution is established, the dosage should be sufficient to reach the target antithrombin activity, and to maintain an effective level. The dosage should determined and monitored on the basis of laboratory measurements of the antithrombin activity, which should be performed at least twice a day until the patient is stabilized, thereafter once a day, preferably immediately before the next infusion. Correction of the dosage should take into account both signs of increased antithrombin turnover according to laboratory controls and clinical course. The antithrombin activity should be maintained above 80% for the duration of the treatment, unless clinical particulars would indicate a different effective level.
It should be kept in mind that the half-life of antithrombin may be substantially shortened in certain clinical conditions, such as disseminated intravascular coagulation.
The usual starting dose in congenital deficiency would be 30-50 IU/kg.
Thereafter, dosage and frequency, as well as duration of treatment should be adjusted to the biological data and clinical situation.


Prophylaxis and treatment of thromboembolic complications in
– hereditary deficiency of antithrombin III
– acquired deficiency of antithrombin III


The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions or all warnings or alerts. Please check with a physician if you have health questions or concerns about interactions or go to the appropriate government authority for a comprehensive list of medical warnings. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

All of the content present on this website, including written text, photographs, videos, graphics, and other resources we might include (these will fall under the collective term of “website”), is meant to educate and should not be perceived as a substitution for professional medical advice, diagnosis or treatment. You should not resort to the website information to arrive at a diagnosis or treatment solution for your health problems or various medical conditions. It does not replace medical care, provided by a medical specialist. In the situation, you have specific symptoms and you might suspect that you are suffering from a medical problem, it is for the best to consult your physician.