Pregadex 150mg capsules
Ingredients in every capsule
Each package contains
|ATC Level 1:||N - Nervous system|
|ATC Level 2:||N03 - Antiepileptics|
|ATC Level 3:||N03A - Antiepileptics|
18 TO 65 YEARS OLD
The dose range is 150 to 600 mg per day given in either two or three divided doses, pregabalin is given with or without food.
The recommended starting dose for pregabalin is 150 mg per day given as two or three divided doses. Based on individual patient response and tolerability, the dose may be increased to 300 mg per day after an interval of 3 to 7 days, and if needed, to a maximum dose of 600 mg per day after an additional week.
The recommended effective starting dose for pregabalin is 75 mg twice daily (150 mg/day) with or without food. Based on individual patient response and tolerability, the dose may be increased to 150 mg twice daily after 1 week, and if needed, to a maximum dose of 300 mg twice daily after an additional week.
Generalized anxiety disorder
The dose range is 150 to 600 mg per day given as two or three divided doses. The need for treatment should be reassessed regularly.
Pregabalin treatment can be started with a dose of 150 mg per day. Based on individual patient response and tolerability, the dose may be increased to 300 mg per day after 1 week. Following an additional week the dose may be increased to 450 mg per day. The maximum dose of 600 mg per day may be achieved after an additional week.
Discontinuation of pregabalin
In accordance with current clinical practice, if pregabalin has to be discontinued, it is recommended this should be done gradually over a minimum of 1 week independent of the indication.
0 TO 18 YEARS OLD
The safety and efficacy have not been established
65 YEARS OLD AND ABOVE
Elderly patients may require a dose reduction of pregabalin due to a decreased renal function.
PATIENTS WITH RENAL IMPAIRMENT
Pregabalin is eliminated from the systemic circulation primarily by renal excretion as unchanged drug. As pregabalin clearance is directly proportional to creatinine clearance, dose reduction in patients with compromised renal function must be individualized according to creatinine clearance (Clcr). Pregabalin is removed effectively from plasma by hemodialysis (50% of drug in 4 hours). For patients receiving hemodialysis, the pregabalin daily dose should be adjusted based on renal function. In addition to the daily dose, a supplementary dose should be given immediately following every 4-hour hemodialysis treatment
PATIENTS WITH HEPATIC IMPAIRMENT
No dose adjustment is required for patients with hepatic impairment.
Pregabalin is indicated as adjunctive therapy in adults with partial seizures with or without secondary generalization.
- Generalized anxiety disorder
Pregabalin is indicated for the treatment of generalized anxiety disorder (GAD) in adults.
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