Ingredients in every vial
Each package contains
|ATC Level 1:||A - Alimentary tract and metabolism|
|ATC Level 2:||A02 - Drugs for Acid Related Disorders|
|ATC Level 3:||A02A - Antacids|
18 YEARS OLD AND ABOVE
Gastric antisecretory treatment when the oral route is not possible.
Patients who cannot take oral medicines may be treated parenterally with 20-40 mg once daily.
Patients with reflux esophagitis should be treated with 40 mg once daily. Patients with symptomatically for reflux disease should be treated with 20 mg once daily.
For healing of gastric ulcers associated with NSAID therapy the usual dose is 20 mg once daily. Usually the IV treatment durations short and transfer to oral treatment should be made as soon as possible.
Maintenance of hemostasis and prevention of rebleeding of gastric and duodenal ulcers following therapeutic endoscopy for acute bleeding gastric or duodenal ulcers, 80 mg should be administered as a bolus infusion over 30 minutes, followed by continuous intravenous infusion of 8 mg/hour given over 3 days (72 hours).
The parenteral treatment period should be followed by acid-suppression therapy with esomeprazole 40 mg gastro-resistant tablet once daily for 4 weeks
0 TO 18 YEARS OLD
Children and adolescent Esomeprazole IV should not be used in children and adolescent since no data is available.
IMPAIRED HEPATIC FUNCTION
Treatment for bleeding ulcer patients with severe liver impairment, following an initial bolus dose of 80 mg esomeprazole for infusion, a continuous intravenous infusion dose of 4 mg/hour for 71.5 hours may be sufficient.
METHOD OF ADMINISTRATION
Injection 40 mg dose The reconstituted solution should be given as an intravenous injection over a period of at least 3 minutes.
Injection 20 mg dose
Half of the reconstituted solution should be given as an intravenous injection over a period of approximately 3 minutes. Any unused solution should be discarded.
Infusion 40 mg dose
The reconstituted solution should be given as an intravenous infusion over a period of 10 to 30 minutes.
Infusion 20 mg dose
Half of the reconstituted solution should be given as an intravenous infusion over a period of 10 to 30 minutes. Any unused solution should be discarded
80 mg bolus dose
The reconstituted solution should be given as a continuous intravenous infusion over 30 minutes.
8 mg/hour dose.
The reconstituted solution should be given as a continuous intravenous infusion over a period of 71.5 hours (calculated rate of infusion of 8 mg/hour).
Esomeprazole injection is indicated for:
– Gastric antisecretory treatment when the oral route is not possible, such as:
– Gastroesophageal reflux disease in patients with esophagitis and/or severe symptoms of reflux.
– Healing of gastric ulcers associated with NSAIDs therapy.
– The short term maintenance of hemostasis and prevention of rebleeding in patients following therapeutic endoscopy for acute bleeding gastric or duodenal ulcers.
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